It's possible with Gilbert as the ambassador of attracting business. I think the Coast cities are out like NYC or SF. Way too expensive to build and operate. I'd narrow the cities to Atlanta or Chicago. Any Texas city and possibly Denver as runner ups.

Detroit definitely performs well as a knowledge center, has a global airport, and relatively good for business. But it's greatly lacking in its technology eco-system, and also lacks the ancillary services and inventory of good residential stock to support 50,000 employees.